From Genes to Proteins: The Impact of Gene Sequence on Translation and Expression

Wednesday, October 28, 2009
4 p.m. GMT, 6 p.m. Bulgarian time



Advances in life science technologies have enabled researchers to gain greater insight into the workings of our genetic code. This includes how subtle changes in gene sequences can impact the expression of encoded proteins through mechanisms including codon bias, mRNA stability, and translation initiation. Natural gene sequences have been shaped in response to many different evolutionary pressures, but are rarely optimal for aspects of "biotechnological fitness," such as maximized protein yield or optimal expression control. In this webinar, out expert guests will discuss the current understanding of how and why gene coding sequences influence protein expression, and ways in which this understanding can help shape strategies to design genes for applications ranging from synthetic biology to protein crystallography.

For more information and to register for the webinar, visit this
LINK

microRNA Research Design: Strategies from the Experts

Tuesday, November 10, 2009
5 p.m. GMT, 7 p.m. Bulgarian time





MicroRNAs, or miRNAs, are increasingly being accepted as playing a crucial regulatory role in normal and dysfunctional cellular processes. They represent a class of small, noncoding RNA molecules, which have been shown to be involved in almost every human pathology currently under study. From tumor progression and viral host interactions, to immune response and stem cell fate determination, miRNAs are quickly growing in importance as the "master regulators" in cell cycle processes. With a wide variety of research tools and potential workflows available, it can be difficult for scientists to determine the optimal path to a successful miRNA research project. This webinar will bring together three recognized experts in miRNA research and experimental design to share their knowledge and expertise.
register

Viewers of the webinar will:

* receive advice on best practices for establishing and running an miRNA research project
* obtain guidance on how to kick-start stalled projects
* hear solutions to common problems encountered in miRNA experiments
* be able to put their specific questions to the panelists live!


To register for this event pleas visit this LINK

Exploring Genetic Diversity: Mapping the Genetic Landscape through Next-Generation Sequencing

Tuesday, August 31, 2010
12 noon Eastern, 9 a.m. Pacific, 4 p.m. GMT

Characterizing the genetic diversity in a population comes with many challenges, one of which is the sheer number of samples needed for an analysis to provide a clear reading of underlying genetic variation. An effective way to solve this problem is through the use of multiplexed polymerase chain reactions (PCR) run with barcoding, which offers the possibility of sequencing hundreds of unique samples per run using next generation sequencing technology. This process, known as amplicon resequencing, allows for each PCR amplicon to be sequenced individually, enabling both the identification of rare variants and the assignment of haplotypes.

This webinar will provide an overview of amplicon resequencing–based approaches, from the perspective of investigating the complexity and diversity seen in immune system genes. Experts will discuss topics such as site-specific recombination reactions and cellular dysfunction, as well as how to utilize cutting-edge technology to discover pathways and specific patterns that impact such factors as the inability of the body to mount an immune response and somatic recombination in antibody production.

To register for this event pleas visit this LINK

Beyond the Knockout Mouse: New Opportunities for Genetic Engineering in Animals

Wednesday, September 15, 2010
12 noon Eastern, 9 a.m. Pacific, 4 p.m. GMT

Until recently, transgenic and knockout models for disease have been limited almost exclusively to mice. Although useful, these models do not always accurately reflect the physiology and pathology of human disease. Now, advances in genetic engineering technology have extended the spectrum of species available beyond mice, enabling the creation of targeted knockouts and knock-ins in rats, rabbits, and zebrafish, with the prospect of achieving precise gene targeting in larger animals, including livestock and nonhuman primates.

Life Science researchers are now presented with an unprecedented opportunity to choose the model system that will best reflect the biology or human disease state being studied. During this Webinar, three expert guests will discuss cutting edge genetic engineering technologies and the opportunities to develop more relevant translational animal models beyond knockout mice.

To register for this event pleas visit this LINK