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IDH1 and IDH2 mutations in myeloid neoplasms - Novel paradigms and clinical implications
Most recent items in "Хематология":
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9th Oct Хематология: Transcriptional silencing of the ETS1 oncogene contributes to human granulocytic differentiation
BackgroundEts-1 is a widely expressed transcription factor implicated in several biological processes including hematopoiesis, where it contributes to the regulation of cellular differentiation. The functions of Ets-1 are regulated by transcription factors as well as by phosphorylation e...
9th Oct Хематология: Cdx4 is dispensable for murine adult hematopoietic stem cells but promotes MLL-AF9-mediated leukemogenesis
BackgroundCdx4 is a homeobox gene essential for normal blood formation during embryonic development in the zebrafish, through activation of posterior Hox genes. However, its role in adult mammalian hematopoiesis has not been extensively studied and its requirement in leukemia associated ... |
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